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回复 140楼michaelr的帖子, x# w# p- S6 }! \( I! h
- F9 G/ ~& ^" s1 F% f6 }8 Z月见草油 并没有你说的的双向调节作用，大豆异黄酮到时有这个作用，但是。% `0 Q6 P E" _8 Y% o
Soy isoflavones An enormous body of literature has accumulated on the hormone-modulating effects of isoflavones, a class of weakly estrogenic phytochemicals. Soy foods are the most important source of isoflavones in the human diet (62) and (63) and ecologic data suggest that populations with high dietary soy intakes have a lower incidence of diseases associated with hormone risk factors (eg, breast cancer) (64). Dietary supplements containing isoflavones are being marketed for breast health; however, to date only small, unpublished studies sponsored by the supplement industry have looked directly at the effects isoflavones may have on breast pain. They claim red clover extract containing some of the same isoflavones found in soy resulted in significant improvement in mastalgia (65). In premenopausal women, isoflavones fed as part of a soy protein supplement have variable effects on menstrual cycle patterns and steroid hormone levels (Table 7). In general, these interventions decrease luteinizing hormone and follicle-stimulating hormone and increase menstrual cycle length.
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; M9 a! u( {' ~: ^4 }7 J, d; H; LThe mechanism of action of soy isoflavones has not been elucidated. At the cellular level, the isoflavones, and genistein in particular, bind to estrogen receptors and can elicit a weak estrogenic response (64), (66) and (67). Researchers have hypothesized that, as a weak estrogen, genistein may compete with estradiol for estrogen receptors, thus reducing a cell's exposure to endogenous estrogen (67), (68), (69) and (70). Although genistein does bind to the estrogen receptor, at physiologic concentrations it also may be acting via other pathways independent of this receptor (64) and (71).
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* _! o. h$ U8 bEffects of isoflavones at the level of the breast epithelium do not provide clear, direct evidence for soy as a dietary treatment for fibrocystic breast conditions. In vitro, genistein has antiproliferative effects on normal human breast epithelial cells (72), and these normal cells are more sensitive than cancer cells to antiproliferative effects of genistein. Short-term, in vivo studies suggest genistein has an estrogenic effect on breast tissue (73), (74) and (75).) q6 F' x& ]# B, Y0 K$ E k
, h0 F9 o" o3 S. u9 ]Currently, there is substantial public interest in soy as a supplement to improve breast health; however, there are no data to support the effectiveness of soy isoflavones in the treatment of fibrocystic breast conditions |
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楼主: michaelr
发表于 2014-12-22 17:45:45
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